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It identified no adequate acute, repeat-dose, genotoxicity, reproductive-toxicity or carcinogenicity programme

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Acknowledgements This work was supported by the National Key Research and Development Program of China (2021YFF1000601), the National Natural Science Foundation of China (32172700) and the Joint Funds of the National Natural Science Foundation of China (U20A2052), and the Fundamental Research Funds for the Central Universities (grant number 2662018PY043)